MRL-494 hydrochloride

Chemical Structure : MRL-494 hydrochloride

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货号: PC-26828Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MRL-494 hydrochloride (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
MRL-494 exhibited antimicrobial activity against a broad range of bacterial species, impairs biogenesis of OMPs and potentiates rifampicin.
MRL-494 impairs biogenesis of OMPs, BamAE470K provides resistance to MRL-494 and restores OMP biogenesis.
MRL-494 inhibits Gram-positive and -negative microbes through distinct mechanisms of action.

物理化学性质&存储条件

分子量	659.13
分子式	C26H36ClFN16O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-carbamimidoyl-3-cyclopropyl-3-((4-((4-(2-(5-(4-fluorophenyl)-2H-tetrazol-2-yl)acetamido)cyclohexyl)amino)-6-guanidino-1,3,5-triazin-2-yl)amino)propanamide hydrochloride

参考文献

1. Elizabeth M Hart, et al. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21748-21757.