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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Enterovirus-MRL-1237
MRL-1237

Chemical Structure : MRL-1237

CAS No.: 276704-21-3

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MRL-1237 (MRL1237)

货号: PC-62926Not For Human Use, Lab Use Only.

MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein.
    MRL-1237 inhibits poliovirus-specific RNA synthesis in HeLa cells infected with a wild strain but not with an F164Y mutant.

    物理化学性质&存储条件

    分子量 354.813
    分子式 C19H16ClFN4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yl)methyl)pyridin-4(1H)-imine hydrochloride

    参考文献

    1. Shimizu H, et al. J Virol. 2000 May;74(9):4146-54.

    2. De Palma AM, et al. J Virol. 2008 May;82(10):4720-30.

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