MRIA9 | dual SIK/PAK inhibitor | Probechem Biochemicals

Chemical Structure : MRIA9

CAS No.: 2750707-05-0

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MRIA9 (MRIA-9)

货号: PC-72723Not For Human Use, Lab Use Only.

MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively.

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2 mg	￥1880	In stock
5 mg	￥2980	In stock
10 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively.
MRIA9 displays excellent selectivity in scanMAX kinase assay panel of 468 kinases.
MRIA9 sensitizes ovarian cancer cells to treatment with the mitotic agent paclitaxel.
MRIA9-induced inhibition of SIK2 blocks the centrosome disjunction, impairs the centrosome alignment, and causes spindle mispositioning during mitosis.
MRIA9 increases chromosomal instability in ovarian cancer cell lines.

物理化学性质&存储条件

分子量	495.939
分子式	C25H23ClFN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(((2r,5r)-5-amino-1,3-dioxan-2-yl)methyl)-3-(2-chloro-4-(3-fluoropyridin-2-yl)phenyl)-7-(methylamino)-1,6-naphthyridin-2(1H)-one

参考文献

1. Tesch R, et al. J Med Chem. 2021 Jun 24;64(12):8142-8160.

2. Raab M, et al. Cancers (Basel). 2021 Jul 21;13(15):3658.

MRIA9 (MRIA-9)

生物&药学活性

物理化学性质&存储条件

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MRIA9 (MRIA-9)

生物&药学活性

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