MRGPRX2 antagonist Compound A

Chemical Structure : MRGPRX2 antagonist Compound A

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货号: PC-23467Not For Human Use, Lab Use Only.

MRGPRX2 antagonist Compound A is a potent, selective MRGPRX2 antagonist with IC50 of 50 nM for inhibition of cortistatin 14-mediated MRGPRX2 activation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MRGPRX2 antagonist Compound A is a potent, selective MRGPRX2 antagonist with IC50 of 50 nM for inhibition of cortistatin 14-mediated MRGPRX2 activation.
Compound A exhibits insurmountable inhibition of Substance P–stimulated LAD2 mast cell degranulation.
Compound A exhibits concentration-dependent inhibition of Cortistatin 14–mediated degranulation with IC50 of 22.8 nM.
Compound A demonstrates excellent selectivity in off-target screening for in vitro secondary pharmacology that included GPCRs, ion channels, and enzymes as targets, including MRGPRX1.
Compound A inhibits substance P–stimulated LAD2 degranulation with IC50 of 32.4 nM.

物理化学性质&存储条件

分子量	218.30
分子式	C13H18N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2,3,3-tetramethyl-N-(pyridin-2-yl)cyclopropane-1-carboxamide

参考文献

1. Macphee CH, et al. Front Immunol. 2024 Oct 18;15:1433982.