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首页-小分子抑制剂&激动剂-GPCR-Mas-related G protein-coupled receptor (MRGPR)-MRGPRX2 antagonist C9
MRGPRX2 antagonist C9

Chemical Structure : MRGPRX2 antagonist C9

CAS No.: 1274013-03-4

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MRGPRX2 antagonist C9 (ZINC49534341)

货号: PC-38068Not For Human Use, Lab Use Only.

MRGPRX2 antagonist C9 is a potent and selective MRGPRX2 inverse agonist (antagonist) with Ki of 43 nM.

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10 mg ￥1580 In stock
25 mg ￥2780 In stock
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纯度 & COA & 质检文件 纯度: 99.9% (HPLC) Select Batch:

生物&药学活性

MRGPRX2 antagonist C9 is a potent and selective MRGPRX2 inverse agonist (antagonist) with Ki of 43 nM.
MRGPRX2 antagonist C9 displays no antagonist activity towards NK1R or MRGPRX4.
MRGPRX2 antagonist C9 inhibits (R)-ZINC-3573-stimulated LAD2 human mast cell degranulation in a concentration-dependent manner.

物理化学性质&存储条件

分子量 275.344
分子式 C12H9N3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(thiazol-2-ylmethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Can Cao, et al. Nature. 2021 Dec;600(7887):170-175.

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