MR837 | NSD2-PWWP1 inhibitor | Probechem Biochemicals

Chemical Structure : MR837

CAS No.: 1210906-48-1

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MR837 (NSD2-PWWP1 inhibitor 3f, MR 837)

货号: PC-72292Not For Human Use, Lab Use Only.

MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells.
MR837 (NSD2-PWWP1 inhibitor 3f) decreased the interaction of NSD2-PWWP1 but not NSD3-PWWP1 with histone 3 in cells in a dose-dependent manner with an IC50 of 17.3 uM.

物理化学性质&存储条件

分子量	282.361
分子式	C16H14N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (2.8 mg/mL)
Chemical Name/SMILES	Benzamide, 4-cyano-N-cyclopropyl-N-(2-thienylmethyl)-

参考文献

1. Renato Ferreira de Freitas, et al. J Med Chem. 2021 Feb 11;64(3):1584-1592.

MR837 (NSD2-PWWP1 inhibitor 3f, MR 837)

生物&药学活性

物理化学性质&存储条件

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MR837 (NSD2-PWWP1 inhibitor 3f, MR 837)

生物&药学活性

物理化学性质&存储条件

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