MR2938 | AChE inhibitor | Probechem Biochemicals

Chemical Structure : MR2938

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MR2938 (MR-2938)

货号: PC-26234Not For Human Use, Lab Use Only.

MR2938 is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 5.04 uM, suppresses NO production in RAW 264.7 cells with IC50 of 3.29 uM.

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生物&药学活性

MR2938 is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 5.04 uM, suppresses NO production in RAW 264.7 cells with IC50 of 3.29 uM.
MR2938 is more potent than Dexamethasone with an IC50 value of 11.5 uM.
MR2938 is able to significantly blocking the LPS-induced expression of pro-inflammatory cytokines IL-1β, TNF-α, IL-6 and CCL2 in BV2 cells.
MR2938 exerts the anti-inflammatory effects through the NF-κB and MAPK/JNK signaling pathways.

物理化学性质&存储条件

分子量	380.45
分子式	C21H24N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,7-Dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl) quinazolin-4(3H)-one

参考文献

1. Lv L, et al. Eur J Med Chem. 2023 Jun 5;254:115346.

2. Lv L, et al. Pharmaceuticals (Basel). 2025 Jan 17;18(1):123.

MR2938 (MR-2938)

生物&药学活性

物理化学性质&存储条件

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MR2938 (MR-2938)

生物&药学活性

物理化学性质&存储条件

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