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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-MPT0L145
MPT0L145

Chemical Structure : MPT0L145

CAS No.: 2070837-24-8

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MPT0L145 (MPT0L 145)

货号: PC-60465Not For Human Use, Lab Use Only.

MPT0L145 is a nove potent, dual FGFR and PIK3C3 inhibitor with Kd of 0.53 nM for PIK3C3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MPT0L145 is a nove potent, dual FGFR and PIK3C3 inhibitor with Kd of 0.53 nM for PIK3C3.
    MPT0L145 inhibits FGFR1 and FGFR3 with Kd of 130 nM and 270 nM, respectively.
    MPT0L145 persistently increases incomplete autophagy, induces cytoplasmic vacuolization in bladder cancer cells.

    物理化学性质&存储条件

    分子量 595.91
    分子式 C25H29Cl3N8O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-1-methyl-3-(2,4,6-trichloro-3,5-dimethoxyphenyl)urea

    参考文献

    1. Chen CH, et al. Clin Cancer Res. 2017 Dec 8. pii: clincanres.2066.2017.

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