MPT0G211 |CAS:2151853-97-1 Probechem Biochemicals

Chemical Structure : MPT0G211

CAS No.: 2151853-97-1

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MPT0G211 (HDAC6 inhibitor)

货号: PC-35288Not For Human Use, Lab Use Only.

MPT0G211 is a potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

MPT0G211 is a potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms.
MPT0G211 significantly inhibits tau phosphorylation on Ser396, Ser404, and phosphorylated tau (p-tau) aggregation.
MPT0G211 significantly attenuates apoptosis induced by p-tau, inhibits HDAC6/Hsp90 binding and causes subsequent proteasomal degradation of polyubiquitinated proteins.
MPT0G211 ameliorates learning and memory impairment in animal models of Alzheimer's disease, reduces the amount of phosphorylated tau in the hippocampal CA1 region.
MPT0G211 also demonstrates antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells.

物理化学性质&存储条件

分子量	293.326
分子式	C17H15N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-4-((quinolin-8-ylamino)methyl)benzamide

参考文献

1. Fan SJ, et al. Cell Death Dis. 2018 May 29;9(6):655.

2. Lee HY, et al. J Med Chem. 2018 Feb 8;61(3):905-917.

MPT0G211 (HDAC6 inhibitor)

生物&药学活性

物理化学性质&存储条件

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MPT0G211 (HDAC6 inhibitor)

生物&药学活性

物理化学性质&存储条件

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