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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-MPT0B390
MPT0B390

Chemical Structure : MPT0B390

CAS No.: 1817802-18-8

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MPT0B390 (B390)

货号: PC-49104Not For Human Use, Lab Use Only.

MPT0B390 (B390) is a selective HDAC1/2 inhibitor and an effective inducer of metalloproteinase 3 (TIMP3), significantly upregulates TIMP3 expression in colorectal cancer cells.

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5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MPT0B390 (B390) is a selective HDAC1/2 inhibitor and an effective inducer of metalloproteinase 3 (TIMP3), significantly upregulates TIMP3 expression in colorectal cancer cells.
MPT0B390 exhibits potent antiproliferative activity against human colon cancer cell line HCT116 with IC50 of 0.03 uM.
MPT0B390 has lower IC50 and greater effect when compared with other commonly used HDAC1/2 inhibitor, SAHA.
MPT0B390 inhibits cell growth of MIA PaCa-2 with IC50 of 0.53 uM, with no effect on normal human pancreatic ductal epithelial cell line (HPDE-E6E7).
MPT0B390 upregulates DUSP2 expression and decreases ERK phosphorylation MIA PaCa-2 cells, exert antitumor effects via reinforcement of DUSP2 expression.
MPT0B390 inhibits pancreatic cancer migration, EV-VEGF-C expression, and proliferation of lymphatic endothelial cells.
MPT0B390 (12.5 mg/kg) reduces tumor-associated lymphangiogenesis and tumor invasion, alleviates cancer malignancy in KPC orthotopic mouse model.

物理化学性质&存储条件

分子量 375.40
分子式 C17H17N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-hydroxy-3-(1-((4-methoxyphenyl)sulfonyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)acrylamide

参考文献

1. Huang HL, et al. Theranostics. 2019 Sep 18;9(22):6676-6689.
2. Pei-Chi Hou, et al. Cancer Res. 2017 Aug 15;77(16):4305-4316.
3. Chu-An Wang, et al. Mol Cancer Ther. 2021 Sep;20(9):1550-1560.

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