MPT0B098 | Microtubule inhibitor, HIF-1α inhibitor | Probechem Biochemicals

Chemical Structure : MPT0B098

加入收藏

MPT0B098 (Microtubule inhibitor)

货号: PC-60910Not For Human Use, Lab Use Only.

MPT0B098 is a potent microtubule inhibitor that not only inhibits the expression levels of HIF-1α protein but also destabilizes HIF-1α mRNA.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MPT0B098 is a potent microtubule inhibitor that not only inhibits the expression levels of HIF-1α protein but also destabilizes HIF-1α mRNA.
MPT0B098 binds to the colchicine-binding site of tubulin, inhibits growth of various human cancer cells, including chemoresistant cells with IC50 70-150 nM.
MPT0B098 exhibit less inhibitory effect against human umbilical vein endothelial cells (HUVEC) with IC50 of 510 nM, arrests cells in the G2-M phase and induces cell apoptosis.
MPT0B098 effectively suppresses tumor growth and microvessel density of tumor specimens in vivo.

物理化学性质&存储条件

分子量	366.43
分子式	C20H18N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((4-methoxyphenyl)sulfonyl)-7-(pyridin-4-yl)indoline

参考文献

1. Cheng YC, et al. Mol Cancer Ther. 2013 Jul;12(7):1202-12.

2. Peng HY, et al. PLoS One. 2016 Jul 1;11(7):e0158440.

3. Chang JY, et al. Medchemcomm. 2010;1(2):152-5.