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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-MPT0B002
MPT0B002

Chemical Structure : MPT0B002

CAS No.: 946077-08-3

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MPT0B002 (MPT0B-002;MPT0B 002)

货号: PC-60553Not For Human Use, Lab Use Only.

MPT0B002 is a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MPT0B002 is a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells.
    MPT0B002 disrupts tubulin polymerization and arrests cell cycle at the G2/M phase.
    MPT0B002 induces apoptosis associated with increased levels of cleaved caspase-3 and cleaved PARP.

    物理化学性质&存储条件

    分子量 325.36
    分子式 C19H19NO4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1-methyl-1H-indol-5-yl)-(3,4,5-trimethoxy-phenyl)-methanone

    参考文献

    1. Yeh YY, et al. Invest New Drugs. 2017 Aug;35(4):427-435.

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