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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-MPPA
MPPA

Chemical Structure : MPPA

CAS No.: 2229897-74-7

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MPPA (Dual sEH/PDE4 inhibitor MPPA)

货号: PC-63331Not For Human Use, Lab Use Only.

MPPA is a potent, orally bioavailable sEH/PDE4 dual inhibitor with IC50 of 2.1 nM and 8.1 nM for hsEH and PDE4, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MPPA is a potent, orally bioavailable sEH/PDE4 dual inhibitor with IC50 of 2.1 nM and 8.1 nM for hsEH and PDE4, respectively.
    MPPA reduces inflammatory pain in lipopolysaccharide induced inflammatory pain rat model.

    物理化学性质&存储条件

    分子量 372.388
    分子式 C18H23F3N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-methoxy-2-(trifluoromethyl)benzyl)-1-propionylpiperidine-4-carboxamide

    参考文献

    1. Blöcher R, et al. J Med Chem. 2018 Apr 10. doi: 10.1021/acs.jmedchem.7b01804.

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