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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-MPK-09
MPK-09

Chemical Structure : MPK-09

CAS No.: 1431884-83-1

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MPK-09 (MPK09;MPK 09)

货号: PC-60182Not For Human Use, Lab Use Only.

A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MPK-09 is a  highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.
    MPK-09 exhibits potent cytotoxic activity against BT474 (p53 E285K) cell line (IC50=0.6 uM) as compared to wt p53 A549 (IC50=2.8 uM) and HeLa (IC50 = 4 uM) cells.
    MPK-09 enhances PARP cleavage, activates caspase 3 expressions and induces apoptosis.

    物理化学性质&存储条件

    分子量 418.53
    分子式 C24H34O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2E)-4-[(4R,5S)-5-[(R)-(Hexyloxy)phenylmethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxo-2-butenoic acid ethyl ester

    参考文献

    1. Metri PK, et al. ACS Chem Biol. 2013 Jul 19;8(7):1429-34.

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