MPI-0479605 | Mps1 inhibitor | Probechem Biochemicals

Chemical Structure : MPI-0479605

CAS No.: 1246529-32-7

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MPI-0479605 (MPI0479605)

货号: PC-43142Not For Human Use, Lab Use Only.

MPI-0479605 is a potent, selective, ATP competitive inhibitor of Mps1 with IC50 of 1.8 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

MPI-0479605 is a potent, selective, ATP competitive inhibitor of Mps1 with IC50 of 1.8 nM.
MPI-0479605 triggers the time-dependent degradation of both cyclin B and securin, decreases BubR1 phosphorylation in nocodazole-arrested cells, blocks apparent autophosphorylation of Mps1 at threonine 676 in HEK293T cells.
MPI-0479605 impairs spindle assembly checkpoint (SAC), resulting in chromosome segregation defects and aneuploidy, induces p53-p21 pathway in an ATM- and ATR-dependent manner.
MPI-0479605 exhibits cytotoxicity across a broad range of tumor cell lines and antitumor activity in human tumor xenografts.

物理化学性质&存储条件

分子量	407.512
分子式	C22H29N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 11 mg/mL
Chemical Name/SMILES	9H-Purine-2,6-diamine, N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-

参考文献

1. Tardif KD, et al. Mol Cancer Ther. 2011 Dec;10(12):2267-75.

2. Vijay Kumar D, et al. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4377-85.

3. Uitdehaag JCM, et al. J Mol Biol. 2017 Jul 7;429(14):2211-2230.

MPI-0479605 (MPI0479605)

生物&药学活性

物理化学性质&存储条件

参考文献

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MPI-0479605 (MPI0479605)

生物&药学活性

物理化学性质&存储条件

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