MP-HJ-1b

Chemical Structure : MP-HJ-1b

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货号: PC-35617Not For Human Use, Lab Use Only.

MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation.

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生物&药学活性

MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation.
MP-HJ-1b shows activities against a panel of more than 1000 human cancer cell lines with a wide variety of tissue origins, also induces the spike-like conformation of microtubules in vitro and in vivo, which is different from typical microtubule modulators.
MP-HJ-1b exhibits an interesting property of general cytotoxicity instead of Ras-mutant-specific killing (A549 KRAS-G12S, IC50=0.04 uM).
MPHJ-1b displayed favorable pharmacological properties for overcoming tumor MDR both in vitro and in vivo.

物理化学性质&存储条件

分子量	373.43
分子式	C21H15N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(benzofuran-2-yl)benzyl)-4H-pyrrolo[2,3-d]thiazole-5-carboxamide

参考文献

1. Ning N, et al. Cancer Res. 2018 Aug 22. pii: canres.0455.2018.

MP-HJ-1b

生物&药学活性

物理化学性质&存储条件

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MP-HJ-1b

生物&药学活性

物理化学性质&存储条件

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