MP-A08 |CAS:219832-49-2 Probechem Biochemicals

Chemical Structure : MP-A08

CAS No.: 219832-49-2

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MP-A08 (MP A08)

货号: PC-45716Not For Human Use, Lab Use Only.

MP-A08 is a first-in-class, highly selective, ATP competitive sphingosine kinase (SphK) inhibitor (Ki of 6.9/27 uM for SK2/SK1).

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

MP-A08 is a first-in-class, highly selective, ATP competitive sphingosine kinase (SphK) inhibitor (Ki of 6.9/27 uM for SK2/SK1).
MP-A08 inhibits S1P production and increases pro-apoptotic sphingolipids in Jurkat cells.
MP-A08 reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis.

物理化学性质&存储条件

分子量	519.6351
分子式	C27H25N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-

参考文献

1. Pitman MR, et al. Oncotarget. 2015 Mar 30;6(9):7065-83.

MP-A08 (MP A08)

生物&药学活性

物理化学性质&存储条件

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MP-A08 (MP A08)

生物&药学活性

物理化学性质&存储条件

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