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MO2455

Chemical Structure : MO2455

CAS No.: 2097009-11-3

MO2455 (MO-2455)

货号: PC-28601Not For Human Use, Lab Use Only.

MO2455 is a synthesized imatinib-derived compound that exert potent cytotoxic effects on leukemia cells with IC50 of 0.83 μM, 0.43 μM and 0.57 μM in U937, THP-1 and CCRF-CEM cells, promotes leukemic cell death by activating the intrinsic apoptotic pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MO2455 is a synthesized imatinib-derived compound that exert potent cytotoxic effects on leukemia cells with IC50 of 0.83 μM, 0.43 μM and 0.57 μM in U937, THP-1 and CCRF-CEM cells, promotes leukemic cell death by activating the intrinsic apoptotic pathway.

物理化学性质&存储条件

分子量 728.89
分子式 C39H36N8O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-([2,2'-bithiophene]-5-carboxamido)-N-(3-((4-(4-(4-ethylpiperazine-1-carbonyl)phenyl)pyrimidin-2-yl)amino)-4-methylphenyl)nicotinamide

参考文献

1. Ankitha Vadi Velu, et al. Cells. 2026 Sep 30;15(19):1780.

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