MO-I-500 | FTO inhibitor | Probechem Biochemicals

Chemical Structure : MO-I-500

CAS No.: 1585219-04-0

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MO-I-500 (FTO inhibitor)

货号: PC-72386Not For Human Use, Lab Use Only.

MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM.

规格	价格	库存
10 mg	￥4880	In stock
25 mg	￥7580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MO-I-500 is a pharmacological inhibitor of m6A demethylase FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM.
MO-I-500 treated cells exhibited a global increase in RNA methylation.
HeLa cells treated with 25 μM MO-I-500 for 24 hours showed a 9.3% increase in N6-methyl-adenosine content in total RNA.
MO-I-500 treatment caused a dramatic (>95%) inhibition in colony formation in SUM149-Luc cells.
MO-I-500 modulates various microRNA in treated (25uM) HeLa cells.
MO-I-500 treatment also led to decreased levels of FTO and IRX3 proteins in the SUM149 cells, with relatively little effect on cell growth.
MO-I-500 can strongly reduce the adverse effects of streptozotocin (STZ) model of AD in human astrocytoma CCF-STTG1 cells.

物理化学性质&存储条件

分子量	317.74
分子式	C12H12ClNO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethanesulfonamide, N-[5-(4-chlorophenyl)-3,4-dihydroxy-2-furanyl]-

参考文献

1. Guanqun Zheng, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):658-65.

2. Singh B, et al. PLoS One. 2016 Jul 8;11(7):e0159072.

3. Cockova Z, et al. ACS Chem Neurosci. 2021 Oct 20;12(20):3818-3828.

MO-I-500 (FTO inhibitor)

生物&药学活性

物理化学性质&存储条件

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MO-I-500 (FTO inhibitor)

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