MO-I-1151

Chemical Structure : MO-I-1151

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货号: PC-22163Not For Human Use, Lab Use Only.

MO-I-1151 is a second-generation small molecule inhibitor of aspartate β-hydroxylase (ASPH), inhibits cholangiocarcinoma (CCA) cell proliferation and migration.

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MO-I-1151 is a second-generation small molecule inhibitor of aspartate β-hydroxylase (ASPH), inhibits cholangiocarcinoma (CCA) cell proliferation and migration.
MO-I-1151 demonstrated more potent inhibitory effects compared to the parent compound MO-I-1100 (Cat# PC-49471).
MO-I-1151 suppressed colony formation in soft agar and CSC sphere formation in H1 CCA cells, and enhanced caspase-3 cleavage.
MO-I-1151 (25 mg/kg, i.p. every other day for 14 days) substantially delayed tumor growth and progression in rat intrahepatic CCA model.

物理化学性质&存储条件

分子量	413.37
分子式	C18H14F3NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-4-oxo-5-(4-(trifluoromethyl)phenyl)-4,5-dihydrofuran-3-yl phenylmethanesulfonate

参考文献

1. Chiung-Kuei Huang, et al. PLoS One. 2016 Mar 8;11(3):e0150336.

MO-I-1151

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MO-I-1151

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