MO-2097 | hnRNPA2B1 inhibitor | Probechem Biochemicals

Chemical Structure : MO-2097

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MO-2097 (MO 2097)

货号: PC-21420Not For Human Use, Lab Use Only.

MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia.

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1 g		Get quote

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生物&药学活性

MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia.
MO-2097 inhibits HIF-1α protein translation and reduces its target gene transcriptional activity, leading to the accumulation of mitochondrial ROS and reduced glucose metabolism.
MO-2097 (25 mg/kg and 50 mg/kg) is a potent inducer of tumor cell apoptosis in the HeLa CCL2 cells xenograft assay, inhibits HIF-1α protein expression and tumor apoptosis in vivo.
MO-2097 attenuates tumor growth in vivo in xenograft HCT116 cell mouse model and colon cancer patient-derived organoids.

物理化学性质&存储条件

分子量	308.33
分子式	C19H16O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(7-methyl-5,8-dihydrooxepino[3,2-f]benzofuran-2-yl)benzene-1,3-diol

参考文献

1. Han HJ, et al. J Adv Res. 2023 Nov 15:S2090-1232(23)00353-3.

MO-2097 (MO 2097)

生物&药学活性

物理化学性质&存储条件

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MO-2097 (MO 2097)

生物&药学活性

物理化学性质&存储条件

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