MNK inhibitor EB1

Chemical Structure : MNK inhibitor EB1

CAS No.: 42951-68-8

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货号: PC-24273Not For Human Use, Lab Use Only.

MNK inhibitor EB1 is potent inhibitor of inhibitor of MNK with IC50 of 0.69 uM (MNK1) and 9.4 uM (MNK2), most likely binds to the allosteric binding side adjacent to the ATP binding pocket.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MNK inhibitor EB1 is potent inhibitor of inhibitor of MNK with IC50 of 0.69 uM (MNK1) and 9.4 uM (MNK2), most likely binds to the allosteric binding side adjacent to the ATP binding pocket.
EB1 selectively inhibits the growth of cancer cells, but not normal cells.
EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation.

物理化学性质&存储条件

分子量	286.34
分子式	C18H14N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6-Diphenyl-1H-pyrazolo[3,4-b]pyridin-3-amine

参考文献

1. Elisabeth Bou-Petit, et al. J Med Chem. 2022 Apr 28;65(8):6070-6087.