MNK inhibitor 9 |CAS:1889336-59-7 Probechem Biochemicals

Chemical Structure : MNK inhibitor 9

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MNK inhibitor 9

货号: PC-61145Not For Human Use, Lab Use Only.

MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).

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25 mg		Get quote
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1 g		Get quote

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生物&药学活性

MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).
MNK inhibitor 9 displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM.
MNK inhibitor 9 inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM.
MNK inhibitor 9 has good solubility and permeability, and is a suitable in vivo tool compound.

物理化学性质&存储条件

分子量	471.569
分子式	C25H29N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(5-Amino-6-(1-methyl-7-(3-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)pyrazin-2-yl)-N,N-dimethylisonicotinamide

参考文献

1. Han W, et al. J Med Chem. 2016 Apr 14;59(7):3034-45.

MNK inhibitor 9

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物理化学性质&存储条件

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MNK inhibitor 9

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