MNKI-8e |CAS:1610886-04-8 Probechem Biochemicals

Chemical Structure : MNKI-8e

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MNKI-8e (MNK inhibitor 8e)

货号: PC-63074Not For Human Use, Lab Use Only.

MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM).

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生物&药学活性

MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM).
MNKI-8e potently inhibits leukemia cells with GI50 of 1.23-7.36 uM (MV4-11 GI50=1.32 uM and KG-1 GI50=1.23 uM).
MNKI-8e blocks phosphorylation of eIF4E, downregulates anti-apoptotic protein Mcl-1 and induces apoptosis in AML cells.
MNKI-8e suppresses the Ara-C-induced MAPK activity and enhances apoptosis in MV4-11 cells.

物理化学性质&存储条件

分子量	358.416
分子式	C17H18N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-((2,4-dimethoxyphenyl)amino)pyrimidin-4-yl)-3,4-dimethylthiazol-2(3H)-one

参考文献

1. Diab S, et al. ChemMedChem. 2014 May;9(5):962-72.

2. Li P, et al. Oncotarget. 2016 Aug 30;7(35):56811-56825.

MNKI-8e (MNK inhibitor 8e)

生物&药学活性

物理化学性质&存储条件

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MNKI-8e (MNK inhibitor 8e)

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物理化学性质&存储条件

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