MNKI-85 |CAS:1812885-57-6 Probechem Biochemicals

Chemical Structure : MNKI-85

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MNKI-85 (MNKI85)

货号: PC-63077Not For Human Use, Lab Use Only.

MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D.

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生物&药学活性

MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D.
MNKI-85 effectively inhibits the growth of AML cells that possess an M5 subtype with FLT3-internal tandem duplication mutation.
MNKI-85 is a powerful pharmacologic tool in studying the Mnk2/eIF4E-mediated tumorigenic mechanism.

物理化学性质&存储条件

分子量	418.487
分子式	C20H23FN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[4-Fluoro-2-(1-methylethoxy)phenyl]amino]-N-(2-methoxyethyl)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

参考文献

1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9.

MNKI-85 (MNKI85)

生物&药学活性

物理化学性质&存储条件

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MNKI-85 (MNKI85)

生物&药学活性

物理化学性质&存储条件

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