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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MNK-MNKI-19
MNKI-19

Chemical Structure : MNKI-19

CAS No.: 1211757-83-3

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MNKI-19 (MNKI19)

货号: PC-63078Not For Human Use, Lab Use Only.

MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MNKI-19 is a potent and dual-specific MAPK-interacting kinase (MNK) inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively.
    MNKI-19  only displays moderate activity against Pim-1 (Ki=2.35 uM) in a panel of upstream activating kinases of Mnks, including B-Raf, MAPK1, MAPK2, Akt1, PI3K, p38α, and mTOR.
    MNKI-19  inhibits the phosphorylation of eIF4E and 4E-BP1, arrests cancer cells in the G1 phase and induce apoptosis in FLT3-ITD expressed AML cells.

    物理化学性质&存储条件

    分子量 361.391
    分子式 C17H16FN3O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-((4-fluoro-2-isopropoxyphenyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid

    参考文献

    1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9.

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