MNK-IN-54 |CAS:1613168-64-1 Probechem Biochemicals

Chemical Structure : MNK-IN-54

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MNK-IN-54

货号: PC-63075Not For Human Use, Lab Use Only.

MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively.

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生物&药学活性

MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively.
MNK-IN-54 also inhibits RET, FLT3, VEGFR2 with IC50 <20 nM.
MNK-IN-54 shows GI50 of 51 nM in the growth of K562 cells overexpressing eIF4E.
MNK-IN-54 exhibits antitumor activity in a mouse xenograft model and also reduces the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.

物理化学性质&存储条件

分子量	584.62
分子式	C30H32F4N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(3-Fluoro-4-((2-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-amino)-2-oxoethyl)amino)phenyl)pyridin-2-yl)cyclopropanecarboxamide

参考文献

1. Cherian J, et al. J Med Chem. 2016 Apr 14;59(7):3063-78.

MNK-IN-54

生物&药学活性

物理化学性质&存储条件

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MNK-IN-54

生物&药学活性

物理化学性质&存储条件

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