MN58b | ChoKα inhibitor | Probechem Biochemicals

Chemical Structure : MN58b

CAS No.: 203192-01-2

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MN58b (MN-58b, ChoKα inhibitor MN58b)

货号: PC-60866Not For Human Use, Lab Use Only.

MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥2980	In stock
10 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism.
MN58b demonstrates antiproliferative properties against human tumor-derived cell lines (HT29 IC50=0.5 uM) and antitumor activity against human tumor xenografts in vivo.

物理化学性质&存储条件

分子量	640.508
分子式	C32H40Br2N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1'-((butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide

参考文献

1. Lacal JC, et al. Mol Cancer Ther. 2015 Jan;14(1):31-9.

2. Hernández-Alcoceba R, et al. Cancer Res. 1999 Jul 1;59(13):3112-8.

3. Al-Saffar NM, et al. Cancer Res. 2006 Jan 1;66(1):427-34.

4. Guma M, et al. Ann Rheum Dis. 2015 Jul;74(7):1399-407.

MN58b (MN-58b, ChoKα inhibitor MN58b)

生物&药学活性

物理化学性质&存储条件

参考文献

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MN58b (MN-58b, ChoKα inhibitor MN58b)

生物&药学活性

物理化学性质&存储条件

参考文献

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