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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-MN551
MN551

Chemical Structure : MN551

CAS No.:

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MN551 (MN 551, MN-551)

货号: PC-21790Not For Human Use, Lab Use Only.

MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.
    MN551 selectively reacts with SOCS2 and CISH over other SOCS family members.
    MN551 shows low cellular permeability.
    MN551 blocks substrate interaction by covalently modifying Cys111 inside the cell.

    物理化学性质&存储条件

    分子量 563.90
    分子式 C25H24ClFN3O7P
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(3-((3-((chlorocarbonyl)amino)benzyl)amino)-2-(2-(4-fluorophenyl)acetamido)-3-oxopropyl)phenyl dihydrogen phosphate

    参考文献

    1. Sarath Ramachandran, et al. Nat Commun. 2023 Oct 10;14(1):6345.

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