MN551 | SOCS2 inhibitor | Probechem Biochemicals

Chemical Structure : MN551

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MN551 (MN 551, MN-551)

货号: PC-21790Not For Human Use, Lab Use Only.

MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.

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生物&药学活性

MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.
MN551 selectively reacts with SOCS2 and CISH over other SOCS family members.
MN551 shows low cellular permeability.
MN551 blocks substrate interaction by covalently modifying Cys111 inside the cell.

物理化学性质&存储条件

分子量	563.90
分子式	C25H24ClFN3O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	FC1=CC=C(CC(N[C@H](C(NCC2=CC=CC(NC(Cl)=O)=C2)=O)CC3=CC=C(OP(O)(O)=O)C=C3)=O)C=C1

参考文献

1. Sarath Ramachandran, et al. Nat Commun. 2023 Oct 10;14(1):6345.

MN551 (MN 551, MN-551)

生物&药学活性

物理化学性质&存储条件

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MN551 (MN 551, MN-551)

生物&药学活性

物理化学性质&存储条件

参考文献

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