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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI4K-MMV390048
MMV390048

Chemical Structure : MMV390048

CAS No.: 1314883-11-8

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MMV390048 (MMV 048, MMV390048)

货号: PC-61691Not For Human Use, Lab Use Only.

MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).
MMV390048 blocks all life cycle stages of the malaria parasite, exhibits full chemoprotection.
MMV390048 delays relapse in a Plasmodium cynomolgi monkey model.

物理化学性质&存储条件

分子量 393.3842
分子式 C18H14F3N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(4-(methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine

参考文献

1. Paquet T, et al. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.

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