MMV1091186 | P.f cIRS inhibitor | Probechem Biochemicals

Chemical Structure : MMV1091186

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MMV1091186 (MMV 1091186)

货号: PC-20099Not For Human Use, Lab Use Only.

MMV1091186 (MMV 1091186) is an antimalarial compound that inhibit P. falciparum cytoplasmic isoleucyl tRNA synthetase (cIRS) with IC50 of 0.87 uM.

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生物&药学活性

MMV1091186 (MMV 1091186) is an antimalarial compound that inhibit P. falciparum cytoplasmic isoleucyl tRNA synthetase (cIRS) with IC50 of 0.87 uM.
MMV1091186 does not compete with ATP, ILE, or tRNA.
MMV1091186 has activity at the liver stage, asexual blood stage, and gametocyte stages aginst malaria life cycle with submicromolar activity.
MMV1091186 inhibits isoleucine transfer to tRNA with an IC50 of 23.8 uM.

物理化学性质&存储条件

分子量	362.48
分子式	C15H14N4OS3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)thio)-4-methylthiazol-5-yl)acetamide

参考文献

1. Istvan ES, et al. Sci Transl Med. 2023 Mar 8;15(686):eadc9249.

2. Yevgeniya Antonova-Koch, et al. Science. 2018 Dec 7;362(6419):eaat9446.

MMV1091186 (MMV 1091186)

生物&药学活性

物理化学性质&存储条件

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MMV1091186 (MMV 1091186)

生物&药学活性

物理化学性质&存储条件

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