MMT3-72 | JAK inhibitor | Probechem Biochemicals

Chemical Structure : MMT3-72

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MMT3-72 (MMT 3-72)

货号: PC-21376Not For Human Use, Lab Use Only.

MMT3-72 is a gastrointestinal locally-activating Janus kinase (JAK) inhibitor, readily converted to MMT3-72-M2 in the colon contents (JAK1 IC50=10.8 nM, JAK2 IC50=26.3 nM and TYK2 IC50=91.6 nM).

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生物&药学活性

MMT3-72 is a gastrointestinal locally-activating Janus kinase (JAK) inhibitor, readily converted to MMT3-72-M2 in the colon contents (JAK1 IC50=10.8 nM, JAK2 IC50=26.3 nM and TYK2 IC50=91.6 nM).
MMT3-72 is inactive but MMT3-72-M2 is more potent against JAK1, 2, and TYK2 by in vitro kinase assays.
MMT3-72 locally activated in the GI tract to release active metabolite MMT3-72-M2 which achieved high exposure in the GI tissues and minimized exposure in the plasma.
MMT3-72 exhibited superior efficacy in treating UC in mice compared with tofacitinib.

物理化学性质&存储条件

分子量	810.88
分子式	C40H42N8O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-(4-((4-((3-(N-(tert-butyl)sulfamoyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)phenoxy)ethoxy)-5-((4-((2-carboxyethyl)carbamoyl)phenyl)diazenyl)benzoic acid

参考文献

1. Yingzi Bu, et al. J Biol Chem. 2023 Nov 16:105467.

MMT3-72 (MMT 3-72)

生物&药学活性

物理化学性质&存储条件

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MMT3-72 (MMT 3-72)

生物&药学活性

物理化学性质&存储条件

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