MMRi62 | Ferroptosis inducer | Probechem Biochemicals

Chemical Structure : MMRi62

CAS No.: 352693-80-2

加入收藏

MMRi62 (MDM2-MDM4 inhibitor MMRi62)

货号: PC-72830Not For Human Use, Lab Use Only.

MMRi62 is a small molecule ferroptosis inducer and MDM2-MDM4-targeting chemical with p53-independent pro-apoptotic activity.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MMRi62 is a small molecule ferroptosis inducer and MDM2-MDM4-targeting chemical with p53-independent pro-apoptotic activity.
MMRi62 inhibits proliferation, clonogenic and spheroid growth of PDAC cells by induction of cell death (IC50=0.59-1.69 uM).
MMRi62-induced cell death in PDAC is characteristic of ferroptosis which is associated with increased autophagy, increased reactive oxygen species and lysosomal degradation of NCOA4 and Ferritin Heavy Chain (FTH1).
MMRi62 also induces proteasomal degradation of mutant p53.
MMRi62-induced ferroptosis occurs in PDAC cell lines harboring either KRAS and TP53 double mutations or single TP53 mutation.
MMRi62 inhibited tumor growth in mice associated with downregulation of NCOA4 and mutant p53 in orthotopic xenograft PDAC mouse models.

物理化学性质&存储条件

分子量	396.271
分子式	C21H15Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((2,3-dichlorophenyl)(pyridin-2-ylamino)methyl)quinolin-8-ol

参考文献

1. Junhui Li, et al. Mol Cancer Ther. 2022 Feb 7;molcanther.0728.2021.

MMRi62 (MDM2-MDM4 inhibitor MMRi62)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MMRi62 (MDM2-MDM4 inhibitor MMRi62)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.