MMRi36

Chemical Structure : MMRi36

CAS No.: 297180-15-5

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货号: PC-23748Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

MMRi36 is a MDM2-MDM4 E3 heterodimer E3 ligase activator, binds and stabilizes MDM2-MDM4 RING domain heterodimer (Kd=308 nM, MST assay), promotes proteasomal degradation of MDM2/MDM4 proteins in cells.
MMRi36 is a potent apoptosis inducer in p53-mutant lymphoma and RRCL cells.
MMRi36 is a potent activator of the E3 complex at concentrations as low as 0.31 μM as indicated by increased ubiquitination of MDM4, MDM2B and p53 during in vitro ubiquitination assays.
MMRi36 promotes ubiquitination and degradation of MDM2/MDM4/p53 associated with apoptosis induction in cells.
MMRi36 promotes XIAP ubiquitination and degradation in cells, induces p53-independent apoptosis.

物理化学性质&存储条件

分子量	360.23
分子式	C15H10BrN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one

参考文献

1. Lama R, et al. Front Oncol. 2024 Dec 23;14:1462231.

MMRi36

生物&药学活性

物理化学性质&存储条件

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MMRi36

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物理化学性质&存储条件

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