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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-MMP13-IN-24f
MMP13-IN-24f

Chemical Structure : MMP13-IN-24f

CAS No.: 458559-34-7

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MMP13-IN-24f

货号: PC-62943Not For Human Use, Lab Use Only.

MMP13-IN-24f is a potent, selective, and orally active MMP-13 inhibitor with IC50/Ki of 0.5/0.19 nM, shows no activity against MMP-1 or TACE (IC50>10 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MMP13-IN-24f is a potent, selective, and orally active MMP-13 inhibitor with IC50/Ki of 0.5/0.19 nM, shows no activity against MMP-1 or TACE (IC50>10 uM).
    MMP13-IN-24f significantly reduces proteoglycan release in rat model of MMP-13-induced cartilage degradation at 30 mg/kg (75% inhibition) and at 10 mg/kg (40% inhibition).

    物理化学性质&存储条件

    分子量 510.62
    分子式 C23H30N2O7S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-{(R)-Carboxy-[5-(4'-ethoxyphenyl)-thiophene-2-sulfonylamino]-methyl}-piperidine-1-carboxylic Acid iso-Propyl Ester

    参考文献

    1. Monovich LG, et al. J Med Chem. 2009 Jun 11;52(11):3523-38.

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