MMP-12 inhibitor 9 | MMP-12 inhibitor | Probechem Biochemicals

Chemical Structure : MMP-12 inhibitor 9

加入收藏

MMP-12 inhibitor 9 (MMP-12i)

货号: PC-20537Not For Human Use, Lab Use Only.

MMP-12 inhibitor 9 is a potent selective MMP-12 inhibitor with IC50 of 177 nM, displays anti-inflammatory activity in vitro and in vivo.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MMP-12 inhibitor 9 is a potent selective MMP-12 inhibitor with IC50 of 177 nM, displays anti-inflammatory activity in vitro and in vivo.
MMP-12 inhibitor 9 is poorly potent against MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, and MMP-13 (IC50>50 uM), displays slightly better inhibitory activity towards MMP-2, MMP-8, and MMP-14 (IC50=2-50 uM).
MMP-12 inhibitor 9 displayed significantly lower lipopolysaccharide- (LPS-) induced lethality compared to vehicle treated controls C57BL/6 mice.
C57BL/6 mice attenuated LPS-induced decrease in tight junction permeability of primary choroid plexus epithelial cells in vitro.

物理化学性质&存储条件

分子量	411.46
分子式	C26H21NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=C(O)C(C=C(C)O1)=O)NCC2=CC=C(C3=CC=C(C4=CC=CC=C4)C=C3)C=C2

参考文献

1. Aerts J, et al. Mediators Inflamm. 2015;2015:510679.