MMK7 inhibitor 4a |CAS 2328096-81-5 Probechem Biochemicals

Chemical Structure : MMK7 inhibitor 4a

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MMK7 inhibitor 4a

货号: PC-36064Not For Human Use, Lab Use Only.

MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7 with IC50 of 10 nM, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M.

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1 g		Get quote

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生物&药学活性

MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7 with IC50 of 10 nM, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M.
MMK7 inhibitor 4a formed a covalent bond to Cys218 at the end of the hinge region of MMK7.
MMK7 inhibitor 4a displayed an excellent selectivity profile at 1 uM against a panel of 320 kinases.
MMK7 inhibitor 4a potently inhibits cellular JNK at 1 uM and completely inhibited its downstream effector c-Jun with no effect on the JNK-pathway.
MMK7 inhibitor 4a is a valuable probe for further investigation to elucidate the function of MKK7 in cellular studies and in vivo.

物理化学性质&存储条件

分子量	457.50
分子式	C23H23N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(3-(3-(1-(4-acetylphenyl)-1H-1,2,3-triazol-4-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one

参考文献

1. Wolle P, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.9b00102.