MMI-0100 | MK2 inhibitor | Probechem Biochemicals

Chemical Structure : MMI-0100

CAS No.: 1039342-24-9

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MMI-0100 (MK2 inhibitor)

货号: PC-38783Not For Human Use, Lab Use Only.

MMI-0100 is a cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), inhibits MK2 and downstream fibrosis and inflammation.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MMI-0100 is a cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), inhibits MK2 and downstream fibrosis and inflammation.
MMI-0100 prevents vein graft intimal thickening ex vivo and in vivo.
MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition.
MMI-0100 treatment reduced cardiac fibrosis, decreased cardiac hypertrophy, and prolonged survival in fibrotic cMyBPC40k disease mice model.

物理化学性质&存储条件

分子量	2283.64
分子式	C98H171N37O26
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	5 mM in PBS
Chemical Name/SMILES	L-Alanine, L-tyrosyl-L-alanyl-L-arginyl-L-alanyl-L-alanyl-L-alanyl-L-arginyl-L-glutaminyl-L-alanyl-L-arginyl-L-alanyl-L-lysyl-L-alanyl-L-leucyl-L-alanyl-L-arginyl-L-glutaminyl-L-leucylglycyl-L-valyl-L-alanyl-

参考文献

1. Akihito Muto, et al. Vascul Pharmacol. Jan-Feb 2012;56(1-2):47-55.

2. Meng Q, et al. J Am Heart Assoc. 2017 Sep 4;6(9):e006590.

3. Xu L, et al. J Mol Cell Cardiol. 2014 Dec;77:86-101.

MMI-0100 (MK2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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MMI-0100 (MK2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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