Chemical Structure : MMG-11
CAS No.: 313254-94-3
货号: PC-38134Not For Human Use, Lab Use Only.
MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥1280 | In stock | |
25 mg | ¥2180 | In stock | |
50 mg | ¥3780 | In stock | |
100 mg | ¥5980 | In stock | |
250 mg | Get quote |
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MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling.
MMG-11 preferentially inhibited TLR2/1 signaling in promoter cells stably expressing TLR2 heterodimers and mouse macrophages.
MMG-11 blocked ligand-induced interaction of TLR2 with MyD88 and reduced MAP kinase and NF-κB activation.
分子量 | 306.27 | |
分子式 | C15H14O7 | |
外观性状 | Solid | |
储存条件 |
|
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate |
1. Grabowski M, et al. Biochem Pharmacol. 2018 Aug;154:148-160.
2. Grabowski M, et al. Biochem Pharmacol. 2020 Jan;171:113687.
3. Bermudez M, et al. ChemMedChem. 2020 Jul 20;15(14):1364-1371.
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