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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-MMG-11
MMG-11

Chemical Structure : MMG-11

CAS No.: 313254-94-3

MMG-11 (MMG11)

货号: PC-38134Not For Human Use, Lab Use Only.

MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling.

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10 mg ¥1280 In stock
25 mg ¥2180 In stock
50 mg ¥3780 In stock
100 mg ¥5980 In stock
250 mg Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling.
MMG-11 preferentially inhibited TLR2/1 signaling in promoter cells stably expressing TLR2 heterodimers and mouse macrophages.
MMG-11 blocked ligand-induced interaction of TLR2 with MyD88 and reduced MAP kinase and NF-κB activation.

物理化学性质&存储条件

分子量 306.27
分子式 C15H14O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 1 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate

参考文献

1. Grabowski M, et al. Biochem Pharmacol. 2018 Aug;154:148-160. 

2. Grabowski M, et al. Biochem Pharmacol. 2020 Jan;171:113687.

3. Bermudez M, et al. ChemMedChem. 2020 Jul 20;15(14):1364-1371.

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