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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-MM3122
MM3122

Chemical Structure : MM3122

CAS No.: 2574390-27-3

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MM3122 (MM-3122)

货号: PC-38259Not For Human Use, Lab Use Only.

MM3122 (MM-3122) is a selective inhibitor of host cell serine protease TMPRSS2 with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein.

规格 价格 库存 数量
5 mg ￥2280 In stock
10 mg ￥3680 In stock
25 mg ￥5580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MM3122 (MM-3122) is a selective inhibitor of host cell serine protease TMPRSS2 with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein.
MM3122 inhibits cytopathic effects induced by SARS-CoV-2 virus in Calu-3 cells with EC50 of 74 nM.
MM3122 blocks host cell entry into Calu-3 human lung epithelial cells of a newly developed VSV-SARS-CoV-2 chimeric virus (EC50=0.43 nM), an EC50 of 74 nM in inhibiting cytopathic effects induced by SARS-CoV-2 virus in Calu-3 cells.
MM3122 inhibits VSV pseudotype MERS viral entry into human Calu-3 lung epithelial cells with EC50 of 0.87 nM.
MM3122 has excellent pharmacokinetics (PK) and safety in mice and is thus a promising lead candidate drug for COVID-19 treatment.

物理化学性质&存储条件

分子量 665.77
分子式 C31H39N9O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 3 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(2-acetamidoacetamido)-N1-((S)-1-(((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pentanediamide

参考文献

1. Mahoney M, et al. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2108728118.

2. Mahoney M, et al. bioRxiv. 2021 May 6:2021.05.06.442935.

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