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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MM-401 TFA
MM-401 TFA

Chemical Structure : MM-401 TFA

CAS No.: 1442106-11-7

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MM-401 TFA (MM401 TFA)

货号: PC-28195Not For Human Use, Lab Use Only.

MM-401 TFA is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.

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2 mg ￥2880 In stock
5 mg ￥4580 In stock
10 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MM-401 TFA is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
MM-401 represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM).
MM-401 specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion.
MM-401 reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.

物理化学性质&存储条件

分子量 700.75
分子式 C31H47F3N8O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide 2,2,2-trifluoroacetate

参考文献

1. Wang M, et al. Acta Pharm Sin B. 2024 Nov;14(11):4899-4913.

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