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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MM-401
MM-401

Chemical Structure : MM-401

CAS No.: 1442106-10-6

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MM-401 (MM 401, MM401)

货号: PC-70114Not For Human Use, Lab Use Only.

MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.

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2 mg ￥2880 In stock
5 mg ￥4580 In stock
10 mg ￥7280 In stock
25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
MM-401 represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM).
MM-401 specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion.
MM-401 reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.

物理化学性质&存储条件

分子量 586.726
分子式 C29H46N8O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide

参考文献

1. Cao F, et al. Mol Cell. 2014 Jan 23;53(2):247-61.

2. Zhang H, et al. Cell Stem Cell. 2016 Apr 7;18(4):481-94.

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