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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MM-102 trifluoroacetate
MM-102 trifluoroacetate

Chemical Structure : MM-102 trifluoroacetate

CAS No.: 1883545-52-5

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MM-102 trifluoroacetate (MM-102 TFA)

货号: PC-42923Not For Human Use, Lab Use Only.

MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM.

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5 mg ￥1480 In stock
10 mg ￥2280 In stock
25 mg ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM.
MM-102 effectively decreases the expression of HoxA9 and Meis-1.
MM-102 specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.

物理化学性质&存储条件

分子量 783.8282
分子式 C37H50F5N7O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide 2,2,2-trifluoroacetate

参考文献

1. Karatas H, et al. J Am Chem Soc. 2013 Jan 16;135(2):669-82.

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