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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-MM-102
MM-102

Chemical Structure : MM-102

CAS No.: 1417329-24-8

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MM-102 (MM102, MM 102)

货号: PC-42922Not For Human Use, Lab Use Only.

MM-102 is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MM-102 is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM.
MM-102 effectively decreases the expression of HoxA9 and Meis-1.
MM-102 specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.

物理化学性质&存储条件

分子量 669.8049
分子式 C35H49F2N7O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclopentanecarboxamide, 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-

参考文献

1. Karatas H, et al. J Am Chem Soc. 2013 Jan 16;135(2):669-82.

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