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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-MLS 0263839
MLS 0263839

Chemical Structure : MLS 0263839

CAS No.: 716375-92-7

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MLS 0263839 (MLS0263839)

货号: PC-62546Not For Human Use, Lab Use Only.

MLS 0263839 is a potent, specific inhibitor of the phosphatase PHOSPHO1 with IC50 of 0.14 uM, shows minimal cross-inhibition of TNAP and no inhibition of ENPP1 activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MLS 0263839 is a potent, specific inhibitor of the phosphatase PHOSPHO1 with IC50 of 0.14 uM, shows minimal cross-inhibition of TNAP and no inhibition of ENPP1 activity.
    MLS 0263839 suppresses vascular smooth muscle cell calcification in cimbined with MLS 0038949.

    物理化学性质&存储条件

    分子量 334.408
    分子式 C15H14N2O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,N-dimethyl-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)benzenesulfonamide

    参考文献

    1. Kiffer-Moreira T, et al. J Bone Miner Res. 2013 Jan;28(1):81-91.

    2. Huesa C, et al. Biochem Biophys Rep. 2015 Dec 1;4:196-201.

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