MLS-0437605 |CAS:862975-18-6 Probechem Biochemicals

Chemical Structure : MLS-0437605

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MLS-0437605 (MLS0437605)

货号: PC-35138Not For Human Use, Lab Use Only.

MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.).

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生物&药学活性

MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.).
MLS-0437605 specifically inhibits collagen- and C-type lectin-like receptor 2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells.

物理化学性质&存储条件

分子量	342.348
分子式	C16H11FN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorobenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine

参考文献

1. Musumeci L, et al. Circulation. 2015 Feb 17;131(7):656-68.

MLS-0437605 (MLS0437605)

生物&药学活性

物理化学性质&存储条件

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MLS-0437605 (MLS0437605)

生物&药学活性

物理化学性质&存储条件

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