MLN4924 hydrochloride | NEDD8-activating enzyme inhibitor

Chemical Structure : MLN4924 hydrochloride

CAS No.: 1160295-21-5

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MLN4924 hydrochloride (Pevonedistat hydrochloride, TAK-924 hydrochloride)

货号: PC-42613Not For Human Use, Lab Use Only.

MLN4924 (Pevonedistat) hydrochloride is an analog of adenosine 5’-monophosphate that potently and selectively inhibits NEDD8-activating enzyme (NAE) with IC50 of 4.7 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MLN4924 (Pevonedistat) hydrochloride is an analog of adenosine 5’-monophosphate that potently and selectively inhibits NEDD8-activating enzyme (NAE) with IC50 of 4.7 nM.
MLN4924 also inhibits the related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 of 1.5 and 8.2 uM, respectively.
MLN4924 disrupts CRL-mediated protein turnover leading to apoptosis in HCT116 cells.
MLN4924 suppresses the growth of human tumor xenografts in mice (30-60 mg/kg).

物理化学性质&存储条件

分子量	479.9803
分子式	C21H26ClN5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 160 mg/mL
Chemical Name/SMILES	Sulfamic acid, [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester, hydrochloride (1:1)

参考文献

1. Soucy TA, et al. Nature. 2009 Apr 9;458(7239):732-6.

2. Milhollen MA, et al. Blood. 2010 Sep 2;116(9):1515-23.

3. Brownell JE, et al. Mol Cell. 2010 Jan 15;37(1):102-11.

MLN4924 hydrochloride (Pevonedistat hydrochloride, TAK-924 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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MLN4924 hydrochloride (Pevonedistat hydrochloride, TAK-924 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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