MLN 3897 |CAS:1010731-97-1 Probechem Biochemicals

Chemical Structure : MLN 3897

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MLN 3897 (AVE 9897)

货号: PC-61966Not For Human Use, Lab Use Only.

MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5.

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生物&药学活性

MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5.
MLN 3897 inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-fos signaling, inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-Fos signaling; demonstrates potential for the treatment of multiple sclerosis and rheumatoid arthritis.

物理化学性质&存储条件

分子量	535.125
分子式	C32H39ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-4-(4-chlorophenyl)-1-(3-(7-(2-hydroxypropan-2-yl)-2,11-dihydrobenzo[6,7]oxepino[3,4-b]pyridin-5(1H)-ylidene)propyl)-3,3-dimethylpiperidin-4-ol

参考文献

1. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.

2. Vallet S, et al. Blood. 2007 Nov 15;110(10):3744-52.

3. Lu C, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):562-8.

4. Vergunst CE, et al. Arthritis Rheum. 2009 Dec;60(12):3572-81.

MLN 3897 (AVE 9897)

生物&药学活性

物理化学性质&存储条件

参考文献

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MLN 3897 (AVE 9897)

生物&药学活性

物理化学性质&存储条件

参考文献

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