MLN3126 |CAS:628300-71-0 Probechem Biochemicals

Chemical Structure : MLN3126

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MLN3126 (MLN 3126;MLN-3126)

货号: PC-35220Not For Human Use, Lab Use Only.

MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization).

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生物&药学活性

MLN3126 (MLN 3126, MLN-3126) is a potent, selective, orally available CCR9 antagonist with IC50 of 6.3 nM (CCL25-induced calcium mobilization).
MLN3126 shows no significant antagonistic activity for other 12 chemokine receptors (CCR1, -2b, -4, -6, -7, -8, -10,CX3CR1, CXCR1, -2, -3 and -4) at 10 uM.
MLN3126 dose dependently inhibits CCL25-induced chemotaxis of mouse thymocytes (IC90=1.8 uM).
MLN3126 ameliorates inflammation in a T cell mediated mouse colitis model.

物理化学性质&存储条件

分子量	446.902
分子式	C21H19ClN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{4-chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(propan-2-yloxy)benzenesulfonamide

参考文献

1. Igaki K, et al. Int Immunopharmacol. 2018 Jul;60:160-169.

2. Narita N, et al. Drug Metab Dispos. 2018 Mar;46(3):204-213.

MLN3126 (MLN 3126;MLN-3126)

生物&药学活性

物理化学性质&存储条件

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MLN3126 (MLN 3126;MLN-3126)

生物&药学活性

物理化学性质&存储条件

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