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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-MLN120B
MLN120B

Chemical Structure : MLN120B

CAS No.: 783348-36-7

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MLN120B (ML120B)

货号: PC-23156Not For Human Use, Lab Use Only.

MLN120B (ML120B) is a potent, specific and ATP competitive inhibitor of IKKbeta (IKKβ) with IC50 of 0.06 uM, blocks TNF-α-induced NF-κB activation in multiple myeloma cells through inhibition of IκBα phosphorylation and degradation of IκBα.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MLN120B (ML120B) is a potent, specific and ATP competitive inhibitor of IKKbeta (IKKβ) with IC50 of 0.06 uM, blocks TNF-α-induced NF-κB activation in multiple myeloma cells through inhibition of IκBα phosphorylation and degradation of IκBα.
ML120B is greater than 1000 times more potent in inhibiting IKKβ than other inhibiting kinases, does not inhibit IKKα.
ML120B inhibited IL-6 and RANTES production in response to LPS in a dose-dependent manner with IC50 of 1 uM on LPS induced primary cells.
ML120B inhibits NF-κB activation and rapidly induces apoptosis in lymphoid organs in vivo.

物理化学性质&存储条件

分子量 366.81
分子式 C19H15ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide

参考文献

1. Hideshima T, et al. Clin Cancer Res. 2006 Oct 1;12(19):5887-94.

2. Hideshima T, et al. Blood. 2009 May 21;113(21):5228-36.

3. Nagashima K, et al. Blood. 2006 Jun 1;107(11):4266-73.

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